Targets of the hypotheses

Everything the published hypotheses propose to act on, with the number of hypotheses standing behind each target.

A larger mark means more hypotheses act on that target. Point at a mark to see its actions

The actions

What can be done to a target depends on what kind of thing it is. An enzyme is inhibited, a receptor is blocked, a gene is silenced. The count is how many times the published hypotheses propose that move.

Inhibition129
Activation51
Lower level13
Higher level2
Replacement5
Protection from degradation3
Cofactor removal0
Synthesis suppression2
Blockade21
Agonism2
Desensitisation0
Function restoration12
Function preservation37
Gene editing3
Silencing4
Expression induction0
Gene replacement therapy0
Excision1
Repair6
Senolysis5
Senomorphic suppression1
Clearance restoration7
Reprogramming3
Transplantation5
Adoptive transfer1
Elimination6
Immunosuppression5
Directed differentiation1
Proliferation0
Population balance7
Neutralisation12
Supplementation13
Accelerated excretion4
Disaggregation1
Aggregation prevention0
Remodelling18
Composition restoration3
Crosslink prevention0
Tissue graft6
Load normalisation10
Feedback restoration9
Rhythm restoration28
Telling states apart35
Direct measurement13
Indicator replacement0
Community restoration0
Colonisation1

The means

What the published hypotheses would act with. The count of records that name no means is published with the rest.

Small molecule32
Antibody or binding reagent4
Protein or peptide as the agent23
RNA interference or antisense4
Genome editing1
Gene delivery4
Cell therapy14
Vaccine or immunisation0
Removal from a body fluid7
Targeted delivery6
Change of environment or regimen66
Physical or surgical intervention45
Microbial intervention1
Instrument or assay49
Controlled genetic model29
Not stated in the record283

Targets of the hypotheses

The actions

The means

Molecules

Genes

Enzymes and receptors

Cells

Tissues and matrix

Processes

Microbial communities

Measurements