Physical property of tissue
Arterial resistance
The resistance that arterial vessels present to blood flow
Hypotheses on this target 1
Remodelling
Composition restoration
Load normalisation1
Direct measurement
Load normalisation1
Better oxygen delivery to restored muscle triggers signals that harm brain and lung circulation
Where this hypothesis actsMuscle graft arteries in an aged host, with contraction and systemic physiological conditions held constant
What is proposedReduce arterial resistance to increase graft oxygen delivery
With whatNot stated in the record
HowLocal arterial dilation while holding contraction, arterial CO2, systemic arterial oxygenation, and systemic pressure constant
Possible resultExpected increased afferent and sympathetic activity, followed by reduced cerebral flow and raised filling pressure
2026-09-20