Live·Open questions in longevity research

Organ structure

Antigen deposits

Antigen-containing structures that present epitopes for recognition and mechanical extraction by B cells

Hypotheses on this target 1

Antigen depositsFunction restoration. Hypotheses on this target 0Remodelling. Hypotheses on this target 11Tissue graft. Hypotheses on this target 0Load normalisation. Hypotheses on this target 0
  • Function restoration
  • Remodelling1
  • Tissue graft
  • Load normalisation

Remodelling1

  • Repeated pulling on antibody-bound deposits governs which immune responses can grow

    Where this hypothesis actsMechanically connected, antibody-crosslinked deposits on FDCs across repeated exposures

    What is proposedRestore the structural integrity of the antigen presentation layer

    With whatNot stated in the record

    HowRepair or replace the presentation layer without changing antibody specificity

    Possible resultExpected reset of damage-history effects on unfamiliar founder output

    2026-09-21