Live·Open questions in longevity research
All targets

Signalling molecule

PGP-family peptides

Chemotactic collagen fragments that recruit and activate neutrophils

Hypotheses on this target 1

PGP-family peptidesLower level. Hypotheses on this target 0Synthesis suppression. Hypotheses on this target 0Neutralisation. Hypotheses on this target 11Supplementation. Hypotheses on this target 0Accelerated excretion. Hypotheses on this target 0
  • Lower level
  • Synthesis suppression
  • Neutralisation1
  • Supplementation
  • Accelerated excretion

Neutralisation1

  • Collagen fragments keep skin inflammation active after normal corpse clearance returns

    Where this hypothesis actsNeutrophil-replenished skin with normalized efferocytosis during repeated mild barrier challenges

    What is proposedSuppress peptide generation or neutralize peptide activity

    With whatNot stated in the record

    HowSelective peptide depletion or neutralization, with measured-concentration peptide add-back to test causality

    Possible resultPossible suppression of recurrent neutrophil activation and matrix damage, allowing barrier recovery

    2026-09-21