Stem cell
Dll1-positive secretory progenitors
Secretory progenitor cells expressing Dll1 that can restore stem cell function
Hypotheses on this target 1
Reprogramming1
Transplantation
Directed differentiation
Proliferation
Population balance
Reprogramming1
Reserve cells may extend life by restoring intestinal crypts after renewal cells are lost
Where this hypothesis actsInitially Lgr5-negative progenitors in intestinal crypts after loss of renewing cells
What is proposedRecruit secretory progenitors to restore functional stem cell lineages
With whatProtein or peptide as the agent
HowLocal, short pulses of Wnt3a, with pulse termination included in the candidate intervention
Possible resultPossible reduction in irreversible crypt loss, supporting intestinal function and lifespan extension
2026-10-05