Live·Open questions in longevity research
All targets

Signalling molecule

NKG2D ligands

Molecules recognized by the activating immune receptor NKG2D

Hypotheses on this target 1

NKG2D ligandsLower level. Hypotheses on this target 11Synthesis suppression. Hypotheses on this target 0Neutralisation. Hypotheses on this target 0Supplementation. Hypotheses on this target 0Accelerated excretion. Hypotheses on this target 0
  • Lower level1
  • Synthesis suppression
  • Neutralisation
  • Supplementation
  • Accelerated excretion

Lower level1

  • Immune killing of normal regenerating cells may favor precancerous clone growth

    Where this hypothesis actsNormal regenerating intestinal cells alongside Apc-altered cells

    What is proposedEliminate NKG2D ligands selectively from normal cells

    With whatControlled genetic model

    HowGenetically restrict ligand changes to normal cells

    Possible resultPossible reduction in later absolute growth of altered clones while preserving autophagic flux

    2026-10-06