Gene and its expression
HLA-II expression
Expression of HLA-II, assessed in the record through its presence on the B-cell surface
Hypotheses on this target 1
Gene editing
Silencing1
Expression induction
Gene replacement therapy
Repair
Silencing1
Memory helper cells can sustain recall responses without the responding cells presenting antigen
Where this hypothesis actsBarcoded recall B cells in aged-donor lymphoid cultures
What is proposedInducibly remove HLA-II expression from recall B cells
With whatControlled genetic model
HowInducible gene perturbation, verifying loss of both endogenous and acquired surface HLA-II by flow cytometry
Possible resultExpected continued multicycle participation and differentiated output despite loss of recipient HLA-II
2026-09-21