Enzyme
ERK
Kinases whose activity transmits signals within cells
Hypotheses on this target 3
Inhibition1
Activation1
Lower level
Higher level
Replacement
Protection from degradation
Cofactor removal
Synthesis suppression
Function preservation
Inhibition1
A final wave of extracellular signal-regulated kinase activity may permit epithelial maturation
Where this hypothesis actsRegenerating epithelium under controlled local hydration, before complete closure
What is proposedEnd further activity waves after the final coordinated wave has crossed the covered area
With whatChange of environment or regimen
HowUse light-controlled signalling constructs to control pulse sequences and fluorescent reporters to track ERK waves and time stimulus withdrawal
Possible resultPossible earlier functional readiness and restored friction tolerance
2026-09-25
Activation1
Hyaluronan fragmentation may blur damage timing signals and delay skin matrix maturation
Where this hypothesis actsDermal fibroblasts exposed to introduced hyaluronan and repeated injury
What is proposedRestore activation sequences aligned with actual injury episodes
With whatNot stated in the record
HowControlled reproduction of ERK activity sequences in an organotypic human dermal fibroblast model, comparing injury-aligned, shifted and shuffled sequences
Possible resultPossible recovery of cellular discrimination between injury and recovery, shortening time to mechanical readiness
2026-09-25