Live·Open questions in longevity research
All targets

Rhythm or programme

Transcription–replication conflicts

Collisions between transcription and DNA replication machinery at the same DNA regions

Hypotheses on this target 1

Transcription–replication conflictsInhibition. Hypotheses on this target 11Activation. Hypotheses on this target 0Function preservation. Hypotheses on this target 0Feedback restoration. Hypotheses on this target 0Rhythm restoration. Hypotheses on this target 0Direct measurement. Hypotheses on this target 0
  • Inhibition1
  • Activation
  • Function preservation
  • Feedback restoration
  • Rhythm restoration
  • Direct measurement

Inhibition1

  • Skin-layer clock mismatch may cause conflicts in copying and reading genetic material

    Where this hypothesis actsRecovering dermal fibroblasts exposed to epidermal interleukin-1 during DNA replication

    What is proposedSuppress transcription–replication conflicts and their associated RNA–DNA hybrids

    With whatGene delivery

    HowTemporarily express nuclear RNase H1 in fibroblasts to remove RNA from RNA–DNA hybrids while preserving clock phases and baseline tissue functions

    Possible resultPossible stabilization of SPV_4 and prevention of prolonged recovery after washing and friction

    2026-09-25