Regulatory protein
PD-L1
A cell-surface protein that engages PD-1 and can suppress signaling in neighboring immune cells
Hypotheses on this target 1
Inhibition
Activation
Lower level1
Higher level
Protection from degradation
Function restoration
Function preservation
Lower level1
Incoming immune cells disrupt resident cells’ antiviral signaling through long pauses
Where this hypothesis actsActivated successor cells contacting protective tissue residents at latent-virus reservoirs
What is proposedEliminate PD-L1 expression in successor cells
With whatControlled genetic model
HowSuccessor-restricted PD-L1 deletion, without preventing predecessor apoptosis
Possible resultExpected restoration of resident signaling reliability and local viral control
2026-09-21