Signalling molecule
Interleukin-1α
A signalling protein involved in inflammatory responses
Hypotheses on this target 3
Lower level
Synthesis suppression
Neutralisation1
Supplementation
Accelerated excretion1
Neutralisation1
Cytokine binding in dead skin cells may store the order of wetting and friction
Where this hypothesis actsBound and available forms in nonliving corneocytes after different sequences of hydration and friction
What is proposedSelectively eliminate its contribution to the proposed biochemical memory
With whatAntibody or binding reagent
HowImmunodeplete it together with its antagonist from extracts; test selective neutralization in intact skin while preserving permeability and mechanical properties
Possible resultExpected loss of memory transfer and stabilization of SPV_1
2026-09-26
Accelerated excretion1
A sweat-borne inflammatory signal is required for persistent friction injury in aged skin
Where this hypothesis actsEccrine-derived IL-1 in sweat contacting aged, photoexposed skin under wet friction
What is proposedDeplete IL-1 from sweat to reduce cytokine delivery
With whatRemoval from a body fluid
HowSelective cytokine immunodepletion, with physiological IL-1 add-back and matched water delivery, pH, salt, temperature, evaporation, and frictional work
Possible resultExpected prevention of persistent inflammatory activation and faster functional barrier recovery
2026-09-21