Live·Open questions in longevity research
All targets

Metabolism and energy

Ubiquitin-dependent proteasomal degradation

The breakdown of ubiquitin-marked proteins by the proteasome

Hypotheses on this target 1

Ubiquitin-dependent proteasomal degradationInhibition. Hypotheses on this target 0Activation. Hypotheses on this target 11Function preservation. Hypotheses on this target 0Supplementation. Hypotheses on this target 0Feedback restoration. Hypotheses on this target 0Direct measurement. Hypotheses on this target 0
  • Inhibition
  • Activation1
  • Function preservation
  • Supplementation
  • Feedback restoration
  • Direct measurement

Activation1

  • Ubiquitin-dependent protein disposal may preserve tissue function despite defective mitophagy

    Where this hypothesis actsDamaged long-lived proteins outside mitochondria, across multiple tissues with defective mitophagy

    What is proposedIncrease ubiquitin-dependent degradation of damaged proteins

    With whatNot stated in the record

    HowSuppress mTOR; the regulator or substrate set responsible for the additional degradation remains to be identified

    Possible resultPossible restoration of enzyme and contractile function despite persistent defective mitophagy

    2026-09-30