Metabolism and energy
Glutamine–glutamate cycle
The cycle of glutamine breakdown to glutamate and glutamine resynthesis that consumes ATP
Hypotheses on this target 1
Inhibition
Activation1
Function preservation
Supplementation
Feedback restoration
Direct measurement
Activation1
Energy spending in the glutamine–glutamate cycle may protect the heart during fasting mimicry
Where this hypothesis actsIn the target tissue during repeated early-fasting mimetic pulses and delayed feeding, tested in cardiomyocytes
What is proposedReproduce a brief local ATP-consuming cycle supported mainly by other fuels
With whatNot stated in the record
HowA proposed mimetic would sustain simultaneous GLS1 and GLUL activity, with other fuels providing most of the energy
Possible resultPossible reduction in respiratory-chain over-reduction, damaging oxidants and residual heart damage
2026-10-06