Live·Open questions in longevity research

Extracellular matrix

Elastin–fibrillin network

A tissue network composed of elastin and fibrillin that supports reversible deformation

Hypotheses on this target 3

Elastin–fibrillin networkProtection from degradation. Hypotheses on this target 0Repair. Hypotheses on this target 0Remodelling. Hypotheses on this target 33Composition restoration. Hypotheses on this target 0Crosslink prevention. Hypotheses on this target 0Tissue graft. Hypotheses on this target 0
  • Protection from degradation
  • Repair
  • Remodelling3
  • Composition restoration
  • Crosslink prevention
  • Tissue graft

Remodelling3

  • Restoring collagen, elastin networks and basement membranes may restore youthful skin function

    Where this hypothesis actsThroughout the selected area of aged skin

    What is proposedRestore the elastin–fibrillin network

    With whatNot stated in the record

    HowOne initial cell-free course without special maintenance treatment; the restoration technology remains to be developed and tested

    Possible resultExpected recovery of reversible skin deformation, contributing to sustained skin function for ten years

    2026-09-26

  • Repairing all three skin matrix components may restore function without replacing cells

    Where this hypothesis actsThroughout the mapped volume of altered dermis

    What is proposedRestore the elastin-fibrillin network to predefined structural limits

    With whatNot stated in the record

    HowRestore the elastic network after collagen correction while retaining existing cells; assess annually and allow at most one matrix correction course per year

    Possible resultExpected restoration of tissue elasticity supporting joint recovery of skin functions

    2026-09-25

  • Restored skin functions and underlying fat support can make collagen repair unnecessary

    Where this hypothesis actsThe entire baseline-deficient portion of dermal elastic fibers

    What is proposedRestore dermal elastic-fiber recoil to the matched youthful range

    With whatNot stated in the record

    HowNot stated in the record

    Possible resultPossible mechanical adequacy of retained aged collagen together with restored hypodermal load sharing

    2026-09-21