Enzyme
Cathepsins
Lysosomal enzymes whose release into the cytosol is proposed to execute cell death
Hypotheses on this target 1
Inhibition1
Activation
Lower level
Higher level
Replacement
Protection from degradation
Cofactor removal
Synthesis suppression
Function preservation
Inhibition1
Estrogen re-exposure may kill breast cell lineages by rupturing deprivation-altered lysosomes
Where this hypothesis actsBreast lineages undergoing lysosomal leakage during estrogen re-exposure after prolonged deprivation
What is proposedSuppress the responsible cathepsins to test their requirement for lineage elimination
With whatNot stated in the record
HowUse independently validated suppression with orthogonal interventions, checking intracellular steroid exposure after each intervention
Possible resultExpected restoration of post-washout clonogenic survival if cathepsins are required for lineage elimination
2026-10-03