Metabolism and energy
Thermal balance
The balance between heat retained by the body and heat lost to its surroundings
Hypotheses on this target 3
Inhibition
Activation
Function preservation3
Supplementation
Feedback restoration
Direct measurement
Function preservation3
Suppressing menopausal hot flashes may impair autonomic recovery by preventing heat loss
Where this hypothesis actsDuring sleep in a heat-sensitive subgroup across natural and induced menopause
What is proposedReduce retained heat and maintain adequate overnight heat disposal
With whatChange of environment or regimen
HowSleep rehabilitation before vasomotor suppression; controlled bedding or room cooling to maintain heat disposal
Possible resultPossible preservation of autonomic recovery, with lasting benefit while improved thermal balance persists
2026-10-03
Delayed heat transfer to cooled peripheral tissues may cause post-flash core cooling
Where this hypothesis actsAfter a flash, when cooled peripheral tissues exchange heat with the core as regional perfusion changes
What is proposedPrevent delayed core-to-periphery heat exchange from causing a core-temperature undershoot
With whatPhysical or surgical intervention
HowTest redistribution by suppressing evaporation and servo-controlling external heat exchange near zero while measuring regional tissue temperature and perfusion
Possible resultPossible prevention of the post-flash core-temperature undershoot and associated awakening
2026-10-03
Local heat buildup may raise oxygen demand and cause hypoxia in the aging kidney
Where this hypothesis actsRenal medulla in an aged kidney after SGLT2 blockade
What is proposedRestore local heat exchange and maintain temperature at the control kidney level
With whatPhysical or surgical intervention
HowControl temperature in a perfused kidney while preserving distal sodium delivery, reabsorption, tubular pressure and oxygen delivery
Possible resultExpected prevention of excess oxygen consumption, tissue hypoxia and loss of renal reserve
2026-09-30