Live·Open questions in longevity research
All targets

Enzyme

ZAKα

A protein implicated in sensing ribosome collisions and activating ribotoxic stress

Hypotheses on this target 1

ZAKαInhibition. Hypotheses on this target 0Activation. Hypotheses on this target 0Lower level. Hypotheses on this target 11Higher level. Hypotheses on this target 0Replacement. Hypotheses on this target 0Protection from degradation. Hypotheses on this target 0Cofactor removal. Hypotheses on this target 0Synthesis suppression. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Inhibition
  • Activation
  • Lower level1
  • Higher level
  • Replacement
  • Protection from degradation
  • Cofactor removal
  • Synthesis suppression
  • Function preservation

Lower level1

  • Estrogen re-exposure may kill deprived breast cell lineages through ribosome collisions

    Where this hypothesis actsEstrogen-deprived breast lineages during estrogen re-exposure

    What is proposedDisrupt ZAKα to test whether it is required for lineage killing

    With whatControlled genetic model

    HowSelectively disrupt ZAKα, then compare complementation with wild-type ZAKα and a collision-sensing-defective construct

    Possible resultExpected preservation of clonogenic survival despite persistent ribosome collisions and matched estrogen signaling

    2026-10-03