Live·Open questions in longevity research
All targets

Structural protein

Filamin C

A structural protein incorporated into sarcomere Z-discs in muscle

Hypotheses on this target 1

Filamin CLower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Replacement. Hypotheses on this target 11Protection from degradation. Hypotheses on this target 0Function preservation. Hypotheses on this target 0Remodelling. Hypotheses on this target 0Crosslink prevention. Hypotheses on this target 0
  • Lower level
  • Higher level
  • Replacement1
  • Protection from degradation
  • Function preservation
  • Remodelling
  • Crosslink prevention

Replacement1

  • Incomplete sarcomere repair may erase a fasting mimetic's lifespan benefit

    Where this hypothesis actsMechanically loaded muscle after a catabolic pulse, with suppressed overall protein synthesis

    What is proposedRestore replacement of damaged filamin C and incorporation of new protein into Z-discs

    With whatGene delivery

    HowCombine a limited damage-removal pulse with local restoration through BAG3 and HSPB8; selective restoration requires a separate genetic construct

    Possible resultPossible preservation of muscle force and lifespan benefits despite low overall anabolism

    2026-10-06