Live·Open questions in longevity research
All targets

Metabolite or ion

Hyaluronan

A water-retaining polymer that occupies space between collagen fibrils and influences their relative movement

Hypotheses on this target 2

HyaluronanSupplementation. Hypotheses on this target 11Accelerated excretion. Hypotheses on this target 0Composition restoration. Hypotheses on this target 0

Supplementation1

  • The fibrosis signal is stopped by the hyaluronan mesh, not by the macrophage

    Where this hypothesis actsAt the macrophage-fibroblast interface in aged human niches with reduced HA molecular weight

    What is proposedRestore high molecular weight hyaluronic acid at the macrophage-fibroblast interface

    With whatProtein or peptide as the agent

    HowAdd exogenous ultra-high molecular weight hyaluronic acid (>6 MDa) to the interface

    Possible resultPossible prevention of TGF-β1-driven fibroblast activation despite high macrophage TGF-β1 secretion

    2026-09-14