Enzyme
PCMT1
An enzyme that repairs isoaspartyl damage in existing proteins
Hypotheses on this target 1
Inhibition
Activation1
Lower level
Higher level
Replacement
Protection from degradation
Cofactor removal
Synthesis suppression
Function preservation
Activation1
Repairing existing muscle proteins may preserve rapamycin’s lifespan benefit without new synthesis
Where this hypothesis actsMuscles during intermittent rapamycin treatment with suppressed restorative protein synthesis
What is proposedIncrease PCMT1 activity
With whatControlled genetic model
HowDevelop a PCMT1 activator or stabilizer; test the principle by inducing muscle expression before restricting translation
Possible resultPossible preservation of muscle function and lifespan benefit despite suppressed protein synthesis
2026-10-05