Live·Open questions in longevity research
All targets

Regulatory protein

β-arrestin-2

A protein implicated in β-arrestin-biased receptor signaling

Hypotheses on this target 1

β-arrestin-2Inhibition. Hypotheses on this target 0Activation. Hypotheses on this target 0Lower level. Hypotheses on this target 11Higher level. Hypotheses on this target 0Protection from degradation. Hypotheses on this target 0Function restoration. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Inhibition
  • Activation
  • Lower level1
  • Higher level
  • Protection from degradation
  • Function restoration
  • Function preservation

Lower level1

  • Resolvins may drive fibrosis in aged cells rather than resolve it

    Where this hypothesis actsAged human macrophages with low FPR2 surface density during resolvin D1 treatment

    What is proposedSuppress β-arrestin-2 using siRNA

    With whatRNA interference or antisense

    HowUse β-arrestin-2 siRNA during resolvin D1 treatment and measure TGF-β1 secretion

    Possible resultExpected blockade of the resolvin D1-induced increase in TGF-β1 secretion

    2026-09-14