Receptor or channel
EP2 receptor
A receptor whose activity can be suppressed
Hypotheses on this target 5
Lower level
Higher level
Blockade5
Agonism
Desensitisation
Function restoration
Function preservation
Blockade5
Neutrophil movement may shift damage between organs and mimic lasting recovery
Where this hypothesis actsDuring blockade of neutrophil engulfment, with prolonged assessment of muscle, lung and heart function
What is proposedSuppress EP2 activity
With whatNot stated in the record
HowNot stated in the record
Possible resultPossible local functional improvement with redistribution of neutrophils and delayed damage in other organs
2026-09-30
Shared lipid synthesis in neutrophils and platelets may limit tissue damage
Where this hypothesis actsResident macrophage environment and coordinated lipid synthesis by neutrophils and platelets
What is proposedSuppress EP2 activity
With whatNot stated in the record
HowNot stated in the record
Possible resultPossible reduction in SPV_3 and new damage across several tissues despite blocked neutrophil engulfment
2026-09-30
Suppressing a prostaglandin receptor may curb ferroptosis through itaconate
Where this hypothesis actsResident macrophages while neutrophil engulfment remains blocked
What is proposedSuppress EP2 to promote itaconate-mediated protection of neighboring cells
With whatNot stated in the record
HowNot stated in the record
Possible resultPossible functional improvement across organs despite persistent neutrophils and their damaging products
2026-09-30
Vesicle removal may limit damage from elastase shielded against its natural inhibitor
Where this hypothesis actsDuring blockade of whole-neutrophil engulfment
What is proposedSuppress EP2 activity
With whatNot stated in the record
HowNot stated in the record
Possible resultPossible restoration of vesicle uptake by macrophages and retention of multisystem benefits
2026-09-30
Delaying neutrophil uptake may preserve vesicle-mediated complement inhibition
Where this hypothesis actsDuring recovery from injury, alongside selective inhibition of neutrophil engulfment
What is proposedSuppress EP2 receptor activity
With whatNot stated in the record
HowNot stated in the record
Possible resultPossible multisystem recovery benefits enhanced by delaying neutrophil engulfment
2026-09-30