Live·Open questions in longevity research
All targets

Metabolism and energy

Hexosamine biosynthesis

A pathway that produces uridine diphosphate N-acetylglucosamine needed for glycosylation and protein maintenance

Hypotheses on this target 1

Hexosamine biosynthesisInhibition. Hypotheses on this target 0Activation. Hypotheses on this target 0Function preservation. Hypotheses on this target 0Supplementation. Hypotheses on this target 11Feedback restoration. Hypotheses on this target 0Direct measurement. Hypotheses on this target 0
  • Inhibition
  • Activation
  • Function preservation
  • Supplementation1
  • Feedback restoration
  • Direct measurement

Supplementation1

  • Muscle glutamine may protect the heart by supplying nitrogen for protein glycosylation

    Where this hypothesis actsTarget tissue, including the heart, during delayed feeding under an early-fasting mimetic

    What is proposedRestore hexosamine flow while reducing dependence on glutamine-derived nitrogen

    With whatSmall molecule

    HowCombine a short pulse of aldometanib with N-acetylglucosamine to bypass the nitrogen-dependent GFAT1 step, provided N-acetylglucosamine reutilization remains functional

    Possible resultPossible preservation of cardiac function and protein quality with less consumption of muscle material

    2026-10-06