Rhythm or programme
Lysosome reformation
The formation of new functional lysosomes through remodeling of autolysosomal membranes after autophagy
Hypotheses on this target 1
Inhibition
Activation1
Function preservation
Feedback restoration
Rhythm restoration
Direct measurement
Activation1
Failed lysosome reformation may erase a fasting mimic's lifespan benefit
Where this hypothesis actsMuscle under prolonged mTORC1 suppression during repeated fasting-mimetic cycles
What is proposedRestore lysosome reformation after autophagy
With whatNot stated in the record
HowRestore the lysosome formation module involving PIP5K1B and clathrin; the record states that no selective drug is available for old muscle
Possible resultPossible recovery of the mimetic's lifespan benefit despite low anabolism
2026-10-06