Live·Open questions in longevity research

Signalling pathway

Neurokinin signaling

Signaling through neurokinin receptors that influences muscle contractile activity

Hypotheses on this target 1

Neurokinin signalingInhibition. Hypotheses on this target 0Activation. Hypotheses on this target 0Desensitisation. Hypotheses on this target 0Function preservation. Hypotheses on this target 11Feedback restoration. Hypotheses on this target 0Rhythm restoration. Hypotheses on this target 0

Function preservation1

  • Senescent-cell secretions change lymphatic pumping and determine when suppression helps

    Where this hypothesis actsCollecting lymphatic muscle after infection, during early or prolonged signaling

    What is proposedMaintain neurokinin signaling within a physiological range

    With whatNot stated in the record

    HowRestore moderate signaling early or selectively reduce excessive signaling late, using cell-restricted neurokinin-receptor perturbation

    Possible resultPossible rescue of early suppression harm and late pumping dysfunction, eliminating the timing reversal

    2026-09-17