Specialised cell of an organ
Adrenal zona fasciculata cells
Steroid-producing cells in the zona fasciculata of the adrenal glands
Hypotheses on this target 1
Function restoration1
Reprogramming
Transplantation
Elimination
Proliferation
Function restoration1
Joint pituitary and adrenal correction may restore hormone pulses and improve multiple functions
Where this hypothesis actsZona fasciculata of both adrenal glands in old mice with defects in both proposed cellular targets
What is proposedRestore adrenocorticotropic hormone response timing in 50% of these cells
With whatControlled genetic model
HowInducible tissue-specific genetic systems, with corrected cells distributed across both adrenal glands; the required fraction needs calibration
Possible resultPossible restoration of corticosterone pulses and three functional trajectories when both populations are corrected
2026-09-30