Receptor or channel
NK1 receptor
A neurokinin receptor involved in vascular responses
Hypotheses on this target 2
Lower level
Higher level
Blockade1
Agonism
Desensitisation
Function restoration1
Function preservation
Blockade1
Scratch commands can renew skin inflammation without skin contact
Where this hypothesis actsPeripheral signaling associated with cutaneous mast-cell activation during scratch motor bouts
What is proposedBlock peripheral substance-P receptor activity
With whatNot stated in the record
HowPeripheral substance-P receptor blockade; no specific blocking agent is stated
Possible resultPossible interruption of inflammation while scratch motor bouts continue
2026-09-21
Function restoration1
Repeated climate transitions may destabilize heat loss by reducing vascular receptor sensitivity
Where this hypothesis actsDuring repeated transitions between humid heat and dry cool conditions
What is proposedAllow receptor responsiveness to recover between successive stimuli
With whatChange of environment or regimen
HowMatch the stimulation interval to the time needed for receptor responsiveness to recover
Possible resultPossible stabilization of heat dissipation and SPV_8 across repeated transitions
2026-09-25