Enzyme
mTOR
A protein whose suppression reduces excessive transcription of ribosomal genes in the proposed pathway
Hypotheses on this target 4
Inhibition4
Activation
Lower level
Higher level
Replacement
Protection from degradation
Cofactor removal
Synthesis suppression
Function preservation
Inhibition4
Reducing ribosomal gene transcription may protect tissues by limiting genome damage
Where this hypothesis actsIn ageing cells, including when mitophagy is suppressed
What is proposedSuppress mTOR activity
With whatSmall molecule
HowTreatment with rapamycin
Possible resultPossible reduction in new genomic damage, preservation of tissue function and reduced malignant transformation
2026-09-30
Ubiquitin-dependent protein disposal may preserve tissue function despite defective mitophagy
Where this hypothesis actsAcross multiple tissues with persistent defective mitophagy
What is proposedSuppress mTOR to increase degradation of damaged proteins
With whatNot stated in the record
HowNot stated in the record
Possible resultPossible sustained functional benefit through clearance of damaged proteins outside mitochondria
2026-09-30
Growth-signal inhibition may release a brake on protein kinase B and limit cell death
Where this hypothesis actsCells in several organs exposed to repeated stress, including when mitophagy is blocked
What is proposedSuppress mTORC1 to restore the brief protective AKT response
With whatNot stated in the record
HowNot stated in the record
Possible resultPossible reduction in stress-induced apoptosis and slower functional deterioration across several systems
2026-09-30
Lysosomal acidity may mimic faster mitochondrial removal
Where this hypothesis actsIn the presence of a lethal tumour, including during actual mitophagy blockade
What is proposedSuppress mTOR
With whatNot stated in the record
HowNot stated in the record
Possible resultPossible lifespan extension through delayed lethal tumour growth without broad functional improvement
2026-09-30