Live·Open questions in longevity research

Extracellular matrix

Basement membranes

Laminin- and collagen-containing matrix structures that support epithelia

Hypotheses on this target 1

Basement membranesProtection from degradation. Hypotheses on this target 0Repair. Hypotheses on this target 0Remodelling. Hypotheses on this target 11Composition restoration. Hypotheses on this target 0Crosslink prevention. Hypotheses on this target 0Tissue graft. Hypotheses on this target 0
  • Protection from degradation
  • Repair
  • Remodelling1
  • Composition restoration
  • Crosslink prevention
  • Tissue graft

Remodelling1

  • Restoring collagen, elastin networks and basement membranes may restore youthful skin function

    Where this hypothesis actsBasement membranes of the epidermis and appendages throughout the selected area of aged skin

    What is proposedRestore the laminin–collagen structure of basement membranes

    With whatNot stated in the record

    HowOne initial cell-free course preserving vessels, nerves and appendages; the restoration technology remains to be developed and tested

    Possible resultExpected stable recovery of the epithelium and appendages, contributing to skin function maintained for ten years

    2026-09-26