Enzyme
DNA polymerase theta
An enzyme that participates in joining broken DNA ends
Hypotheses on this target 1
Inhibition
Activation
Lower level
Higher level1
Replacement
Protection from degradation
Cofactor removal
Synthesis suppression
Function preservation
Higher level1
Polymerase theta repair may extend life by sealing persistent genetic breaks with mutations
Where this hypothesis actsLong-lived cells with persistent DNA breaks that sustain inflammatory secretion in an old organism
What is proposedBriefly increase polymerase-mediated joining of broken DNA ends
With whatControlled genetic model
HowInducible polymerase expression for cellular testing; targeted closure of persistent breaks in an old organism remains technically unresolved
Possible resultPossible lasting reduction in damage transmission and longer remaining life despite increased insertions and deletions
2026-09-30