Live·Open questions in longevity research
All targets

Receptor or channel

NKG2D receptor

An activating immune receptor that recognizes cellular ligands

Hypotheses on this target 1

NKG2D receptorLower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Blockade. Hypotheses on this target 11Agonism. Hypotheses on this target 0Desensitisation. Hypotheses on this target 0Function restoration. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Lower level
  • Higher level
  • Blockade1
  • Agonism
  • Desensitisation
  • Function restoration
  • Function preservation

Blockade1

  • Immune killing of normal regenerating cells may favor precancerous clone growth

    Where this hypothesis actsDuring the overlapping spermidine, feeding and immune peak in aged mice with mosaic intestinal cells

    What is proposedBriefly block NKG2D during the regeneration-associated recognition window

    With whatNot stated in the record

    HowApply a short NKG2D blockade restricted to the overlap window

    Possible resultPossible reduction in later absolute growth of altered clones while preserving autophagic flux

    2026-10-06