Signalling molecule
Tumstatin
A fragment released from collagen IV that suppresses tumor vascularization
Hypotheses on this target 1
Lower level
Synthesis suppression
Neutralisation
Supplementation1
Accelerated excretion
Supplementation1
Correcting bone remodeling may remove tumstatin's restraint on tumor blood-vessel growth
Where this hypothesis actsIn circulation during correction of menopause-associated excessive skeletal remodeling
What is proposedRestore circulating tumstatin to its pretreatment concentration
With whatProtein or peptide as the agent
HowRecombinant-fragment rescue alongside selective suppression of osteoclast remodeling
Possible resultPossible prevention of cancer acceleration while retaining the skeletal benefit
2026-10-03