Live·Open questions in longevity research
All targets

Enzyme

ADAR1

An enzyme that edits RNA, limiting recognition of endogenous RNA by MDA5

Hypotheses on this target 1

ADAR1Inhibition. Hypotheses on this target 0Activation. Hypotheses on this target 0Lower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Replacement. Hypotheses on this target 11Protection from degradation. Hypotheses on this target 0Cofactor removal. Hypotheses on this target 0Synthesis suppression. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Inhibition
  • Activation
  • Lower level
  • Higher level
  • Replacement1
  • Protection from degradation
  • Cofactor removal
  • Synthesis suppression
  • Function preservation

Replacement1

  • Underedited ribonucleic acid may sustain inflammation through an interferon feedback loop

    Where this hypothesis actsIn tissue cells with persistent, inadequately edited double-stranded RNA after prior stress

    What is proposedRestore catalytically active ADAR1 and its RNA-editing activity

    With whatNot stated in the record

    HowRestore catalytically active ADAR1, using a catalytically inactive variant as a comparison

    Possible resultPossible prevention of inflammatory relapse that persists after the intervention is withdrawn

    2026-09-30