Specialised cell of an organ
Hepatocytes
Liver cells that produce and secrete proteins, including apolipoprotein B (APOB)
Hypotheses on this target 1
Function restoration1
Reprogramming
Transplantation
Elimination
Proliferation
Function restoration1
Errors in liver-made apolipoprotein B may damage blood vessels, muscles and glucose control
Where this hypothesis actsMature hepatocytes accounting for 50% of APOB production, excluding perivenous glutamine synthetase-expressing cells
What is proposedImprove protein synthesis accuracy in the selected hepatocytes
With whatGene delivery
HowTargeted genetic interventions; RPS23 K60R transfer first requires testing translation accuracy, synthesis speed and cell viability
Possible resultPossible improvements in vascular function, muscle strength, glucose tolerance and remaining lifespan
2026-09-30