Enzyme
Glucose-6-phosphate dehydrogenase
An enzyme whose catalytic activity supports production of reduced nicotinamide adenine dinucleotide phosphate
Hypotheses on this target 1
Inhibition
Activation
Lower level
Higher level
Replacement
Protection from degradation
Cofactor removal
Synthesis suppression
Function preservation1
Function preservation1
Molecular crowding may shift enzyme forms to preserve rapid antimicrobial defense
Where this hypothesis actsIn descendants of haematopoietic stem cells during attenuation of chronic inflammatory memory
What is proposedMaintain sufficient catalytic activity while weakening chronic secretion
With whatPhysical or surgical intervention
HowAlter available cytoplasmic volume to shift the equilibrium between enzyme forms; measure their specific activities separately
Possible resultPossible preservation of the rapid antimicrobial oxidative response
2026-09-30