Metabolite or ion
Extracellular electrolytes
Ions in the fluid outside cells that constitute the local electrolyte environment
Hypotheses on this target 1
Supplementation
Accelerated excretion
Composition restoration1
Composition restoration1
Earlier sweating after heat acclimatization may trigger a local vessel-narrowing reflex
Where this hypothesis actsAround sweat ducts during prolonged contact with hypotonic sweat after heat acclimatization
What is proposedAdjust the local ionic composition to prevent initiation of the vasoconstrictor reflex
With whatChange of environment or regimen
HowChange the ionic composition of applied artificial sweat while controlling osmolality and keeping surface liquid quantity constant
Possible resultPossible preservation of local blood flow and epidermal barrier recovery during wet exposure
2026-09-25