Live·Open questions in longevity research
All targets

Indicator or biomarker

Skin ageing index

A composite measure that combines outcomes across domains of skin ageing

Hypotheses on this target 1

Skin ageing indexTelling states apart. Hypotheses on this target 11Direct measurement. Hypotheses on this target 0Indicator replacement. Hypotheses on this target 0

Telling states apart1

  • Averaging, swelling or early sampling may make independent skin improvements look coordinated

    Where this hypothesis actsSkin of 50-year-olds assessed against a 30-year-old reference after selective and combined interventions

    What is proposedDistinguish aggregate improvement from sustained normalization of every measured domain

    With whatInstrument or assay

    HowMeasure domains separately over time, with predefined criteria and clinically meaningful thresholds, including after interventions stop

    Possible resultExpected persistence of at least one domain deficit despite improvement in the overall index

    2026-09-29