Indicator or biomarker
Invasion measurement
An assessment of cell invasion based on apparent depth or actual crossing of the basement membrane
Hypotheses on this target 1
Telling states apart1
Direct measurement
Indicator replacement
Telling states apart1
Tissue deformation makes restored skin flexibility appear to promote abnormal cell spread
Where this hypothesis actsAt the basement membrane displaced or folded under shear after compliance restoration
What is proposedDistinguish actual basement-membrane crossing from displacement below a reference plane
With whatInstrument or assay
HowUse volumetric imaging with fiducials and labeled basement membrane to continuously track its surface, with paired loaded/unloaded measurements and fixed-tissue controls
Possible resultExpected disappearance of apparent invasion when displacement is distinguished from basement-membrane crossing
2026-09-21