Extracellular nucleic acid
Double-stranded RNA
RNA molecules with two paired strands that can be recognized by MDA5 and trigger an interferon response
Hypotheses on this target 1
Silencing1
Clearance restoration
Neutralisation
Accelerated excretion
Silencing1
Underedited ribonucleic acid may sustain inflammation through an interferon feedback loop
Where this hypothesis actsIn tissue cells after prior stress, where inadequately edited transcripts persist after the initial stimulus is removed
What is proposedSelectively eliminate the causal double-stranded RNA transcripts
With whatNot stated in the record
HowBrief, targeted degradation of the implicated RNA transcripts
Possible resultPossible interruption of the self-sustaining interferon cycle and prevention of inflammatory relapse
2026-09-30