Live·Open questions in longevity research
All targets

Signalling pathway

Endothelium-dependent vasodilation

A vascular response mediated by the endothelium through nitric oxide that supports blood flow

Hypotheses on this target 1

Endothelium-dependent vasodilationInhibition. Hypotheses on this target 0Activation. Hypotheses on this target 0Desensitisation. Hypotheses on this target 0Function preservation. Hypotheses on this target 11Feedback restoration. Hypotheses on this target 0Rhythm restoration. Hypotheses on this target 0

Function preservation1

  • Weak backup blood flow may leave treated skin vulnerable when nerve-driven responses fade

    Where this hypothesis actsTreated skin with a weakened endothelial nitric oxide pathway during sequential loads

    What is proposedRestore the endothelial pathway's capacity to provide a sufficient vascular response

    With whatNot stated in the record

    HowNot stated in the record

    Possible resultPossible stabilization of SPV_8 and prevention of subsequent heat-loss and barrier-recovery disturbances

    2026-09-25