Signalling molecule
Cryptic collagen ligands
Normally hidden collagen sites that become exposed by cleavage and can engage integrin signaling
Hypotheses on this target 1
Lower level
Synthesis suppression
Neutralisation1
Supplementation
Accelerated excretion
Neutralisation1
Do exposed collagen patches trigger cell contraction that reopens repaired attachments?
Where this hypothesis actsMatrix surrounding aged dermal fibroblasts, where clustered collagen proteolysis exposes dense ligand patches
What is proposedMask cleavage-exposed collagen epitopes to prevent local signaling
With whatNot stated in the record
HowUse epitope-selective masking; test patterned versus diffuse epitope presentation with mechanically negligible carriers and inactive-peptide controls
Possible resultPossible prevention of delayed cellular traction and attachment reopening without changing collagen connectivity
2026-09-21