Mechanics and load
Collagen crosslinking
The formation of crosslinks that stabilize collagen within the extracellular matrix
Hypotheses on this target 1
Inhibition
Activation
Function preservation
Remodelling1
Load normalisation
Direct measurement
Remodelling1
Competition among skin cells drives collagen crosslinking beyond what tissue can withstand
Where this hypothesis actsAged human dermal constructs during matrix deposition following expansion and before filler resorption
What is proposedLimit pericellular crosslinking uniformly across competing fibroblasts
With whatControlled genetic model
HowInducible modulation of lysyl-oxidase activity across competing fibroblasts during matrix deposition, with collagen abundance matched
Possible resultPossible improvement in later tissue fatigue resistance and wound maturation at matched collagen abundance
2026-09-21