Live·Open questions in longevity research
All targets

Signalling molecule

Interleukin-22

An immune signalling molecule implicated in epidermal barrier recovery after microinjury

Hypotheses on this target 1

Interleukin-22Lower level. Hypotheses on this target 0Synthesis suppression. Hypotheses on this target 0Neutralisation. Hypotheses on this target 11Supplementation. Hypotheses on this target 0Accelerated excretion. Hypotheses on this target 0
  • Lower level
  • Synthesis suppression
  • Neutralisation1
  • Supplementation
  • Accelerated excretion

Neutralisation1

  • Skin lipids may slow repair by blocking immune recognition and its repair signal

    Where this hypothesis actsHuman skin after stress and brief activation of autologous CD1a-reactive T cells

    What is proposedBlock interleukin-22 to test whether it mediates restored barrier recovery

    With whatNot stated in the record

    HowInterleukin-22 blockade after T-cell activation; the blocking agent is not stated

    Possible resultExpected loss of the recovery restored by T-cell activation

    2026-09-26