Rhythm or programme
Endocrine–circadian phase relationship
The timing of endocrine signals relative to the phase of tissue circadian clocks
Hypotheses on this target 1
Inhibition
Activation
Function preservation
Feedback restoration
Rhythm restoration1
Direct measurement
Rhythm restoration1
Mistimed endocrine signals may impair recovery by misaligning with tissue circadian clocks
Where this hypothesis actsPerimenopause, initially tested in synchronized participant-derived cultures
What is proposedAlign endocrine signals with tissue circadian phase
With whatChange of environment or regimen
HowTime otherwise identical endocrine waveforms to measured circadian phases while matching average exposure, amplitude, pulse spacing and receptor recovery
Possible resultPossible improvement in metabolic and autonomic recovery with more reproducible endocrine-to-functional response timing
2026-10-03