Aggregate or deposit
Amyloid seeds
Protein material carrying a transmissible conformation that can impose itself on compatible tissue
Hypotheses on this target 2
Clearance restoration
Neutralisation1
Accelerated excretion1
Disaggregation
Aggregation prevention
Neutralisation1
Persistent protein seeds make replacement tissue fail sooner
Where this hypothesis actsEndocrine replacement sites in human-IAPP-expressing models, across successive graft generations
What is proposedNeutralize persistent aggregate seeds
With whatNot stated in the record
HowUse aggregate-targeting reagents for selective seed neutralization or depletion while leaving interface permeability, mechanics, and delivered tissue mass unchanged
Possible resultPossible stabilization of SPV_10 and restoration of graft failure latency
2026-09-17
Accelerated excretion1
Conditioning releases host protein seeds that shorten replacement tissue durability
Where this hypothesis actsLocal extracellular compartment at conditioned replacement interfaces in amyloid-positive aged hosts
What is proposedSuppress seeding activity by depleting amyloid seeds
With whatRemoval from a body fluid
HowUse seed immunodepletion and protein-specific depletion controls, matching soluble inflammatory components and checking unintended removal of other bioactive material
Possible resultExpected loss of the late conditioning disadvantage despite identical handoff delays
2026-09-18