Metabolism and energy
Lactate-to-glucose recycling
A process in which lactate produced by muscle is converted into glucose by the liver and returned to muscle
Hypotheses on this target 1
Inhibition1
Activation
Function preservation
Supplementation
Feedback restoration
Direct measurement
Inhibition1
Liver energy demand from lactate recycling may sustain a costly muscle–liver feedback loop
Where this hypothesis actsMuscle and liver after ordinary activity in a proposed subset of aging humans with excessive recycling
What is proposedReduce excessive lactate-to-glucose recycling
With whatNot stated in the record
HowA proposed liver-restricted recycling perturbation that preserves glucose availability and necessary compensation; no selective intervention is supplied
Possible resultPossible improvement in sustained muscle recovery without increasing intrinsic muscle respiratory capacity
2026-10-10