Signalling molecule
Corticosterone
A hormone whose concentration follows a pulsatile temporal profile
Hypotheses on this target 1
Lower level
Synthesis suppression
Neutralisation
Supplementation1
Accelerated excretion
Supplementation1
Joint pituitary and adrenal correction may restore hormone pulses and improve multiple functions
Where this hypothesis actsHormonal pulse profiles in old mice undergoing mediator replacement or profile reproduction experiments
What is proposedReproduce the restored corticosterone pulse profile
With whatSmall molecule
HowProgrammable corticosterone administration; replace restored pulses with the original aged profile at equal daily exposure to test mediation
Possible resultPossible improvements in vascular function, muscle recovery and glucose metabolism
2026-09-30