Gene and its expression
Antimicrobial protein coding sequences
Nucleotide sequences that specify the amino acid sequences of antimicrobial proteins
Hypotheses on this target 1
Gene editing1
Silencing
Expression induction
Gene replacement therapy
Repair
Gene editing1
Queuosine modification may separate antimicrobial protection from inflammatory damage
Where this hypothesis actsA protective protein yet to be identified in myeloid cells with inflammatory memory
What is proposedReplace modification-sensitive codons with synonymous codons
With whatGenome editing
HowUse synonymous substitutions that preserve the protein's amino acid sequence and comparable messenger RNA abundance and stability
Possible resultPossible restoration of early protective function after inflammatory memory is weakened
2026-09-30