Live·Open questions in longevity research
All targets

Metabolism and energy

Oxidative metabolism

Metabolic processes that consume oxygen, including the oxidation of fatty acids

Hypotheses on this target 1

Oxidative metabolismInhibition. Hypotheses on this target 0Activation. Hypotheses on this target 11Function preservation. Hypotheses on this target 0Supplementation. Hypotheses on this target 0Feedback restoration. Hypotheses on this target 0Direct measurement. Hypotheses on this target 0
  • Inhibition
  • Activation1
  • Function preservation
  • Supplementation
  • Feedback restoration
  • Direct measurement

Activation1

  • Restoring oxygen consumption in colon cells may limit pathological clones after regeneration

    Where this hypothesis actsMature colonocytes after intestinal repair, when a prolonged regenerative programme leaves more oxygen for bacteria

    What is proposedRestore oxygen consumption through oxidative metabolism

    With whatSmall molecule

    HowLocal, late mesalazine treatment, with tests of dependence on PPARγ and colonocyte oxidative metabolism

    Possible resultPossible reduction in bacterial respiratory growth, repeated inflammatory injury and tumour mortality

    2026-10-05