Live·Open questions in longevity research
All targets

Stem cell

Myeloid-biased long-term hematopoietic stem cells

Long-term blood-forming stem cells with myeloid-biased output

Hypotheses on this target 1

Myeloid-biased long-term hematopoietic stem cellsReprogramming. Hypotheses on this target 0Transplantation. Hypotheses on this target 11Directed differentiation. Hypotheses on this target 0Proliferation. Hypotheses on this target 0Population balance. Hypotheses on this target 0
  • Reprogramming
  • Transplantation1
  • Directed differentiation
  • Proliferation
  • Population balance

Transplantation1

  • Can replacing biased blood-forming stem cells alone deliver lasting benefits against aging?

    Where this hypothesis actsThroughout axial and proximal appendicular marrow in the baseline stem-cell compartment

    What is proposedReplace 90% of the myeloid-biased compartment with balanced-output stem cells

    With whatCell therapy

    HowSelective depletion and transplantation in one initial event; preserve balanced host HSCs, marrow mesenchymal stroma, thymic epithelium, and all nonhematopoietic tissues

    Possible resultPossible sustained balanced blood-cell output and prevention of immune-metabolic recovery deficits over 20 years

    2026-09-18